Network: ABC/CBS

Nobody thought this Perfect Strangers spin-off would last for nearly a decade, but Family Matters went on to become one of the longest-running sitcoms with a predominantly African-American cast.

Set in Chicago, it told the story of the Winslow family, a middle-class bunch led by parents Carl and Harriette. When the show began, they had three children: Eddie, Laura, and Judy. Sometime after the fourth season, Judy was inexplicably written out, leaving viewers wondering what happened to her years after the show ended. As it turns out, actress Jaimee Foxworth dabbled in the adult entertainment industry and ended up on Celebrity Rehab with Dr. Drew.

Joining the nuclear family at the Winslow home was Carl's all-knowing mother, Estelle, Hariette's sister Rachel and her young son Richie. But as history has made clear, the true star of the show was Jaleel White's Steven Q. Urkel, the annoying neighbor introduced halfway through the show's first season.

Urkel charmed audiences with his unrequited love for Laura. Of course, the equally nerdy Myra Monkhouse shook this up, a sign that the writers were looking for a change. Not long there after, the "Stefan Urquelle" character was created, and Laura found herself drawn to him despite the fact that he was simply Steve minus the nerdy disguise.

Family Matters was part of ABC's famous TGIF Friday lineup that kids stayed up for on a weekly basis, fueled by pizza and soda. The show existed in the same fictional universe as other TGIF shows, crossing over with the likes of Perfect Strangers, Step by Step, Full House, and Boy Meets World.