36. Shrink Ray
Duke Nukem series
The Shrink Ray isn't exactly an original idea, but Duke Nukem 3D was almost definitely the first game to include one. It was perfectly in keeping with Duke's lack-of-fuck-giving to shrink down his foes to a stompable level, and he even continued the habit in Duke Nukem Forever, though we try not to mention that one if we can help it.