Meme Origin: Manny Pacquiao's shocking knockout loss to Juan Manuel Marquez.

Over the last 10 years, Manny Pacquiao has transformed himself from a virtually unknown bantamweight fighter to an eight-division world champion and global icon. No one's invincible though, especially in the world of boxing. Pac-Man found out the hard way on Saturday when Juan Manuel Marquez delivered the Knockout of the Year in the sixth round. The shocking image of Pacquiao laid out on the canvas created the perfect opportunity those on the Interwebs to go to work. From Trinidad James rolling over the fallen boxer to Simba trying to wake up Pac-Man, the memes were pretty hilarious.