The 25 Hottest Muses of All Time

With the release of The Rum Diary this Friday, Johnny Depp and Amber Heard's onscreen relationship as writer Paul Kemp and the sultry socialite Chenault has us recalling some of the greatest muses in pop culture history. Without the influence of these beautiful women upon some of the most creative and world-changing minds, many of the classics we hold dear today would have never become the subject of our nostalgia. There'd be no Annie Hall if Allen never met Keaton and no "Layla" if Clapton never came across Boyd. Continue reading to draw inspiration from The 25 Hottest Muses of All Time.

RELATED: The 100 Hottest Women Ever

Designer: Alexander McQueen
Credited for discovering one of the world’s beloved designers, the late Alexander McQueen, Isabella Blow’s contribution to the fashion industry is as significant as the threads that create an article of clothing. Blow had a unique talent of discovering and uncovering artists, and McQueen was enraptured by it, thus creating a sophisticated fashion brand that’s still worn and loved by many today.

Designer: Yves St. Laurent
Loulou De La Falaise is not only Yves St. Laurent’s muse, but also his designing partner. The French beauty, who had famously grown up around fashion with her mom Maxime de la Falaise as a notable fashionista, is said to have inspired YSL’s female tuxedo and see-through blouses. So, don’t forget to thank her when you see another hot chick rocking the trend.

Designer: Nicolas Ghesquiere
Perhaps what drew Nicolas Ghesquiere to the actress wasn’t her overt appeal, but her quiet yet bold navigation through the film, fashion and music worlds. Gainsbourg, who has starred in Lars Von Trier’s Antichrist and released several folk-rock albums, also shares Ghesquière's taste in radical and edgy style that's not too gaudy or blatantly high-fashion.

Musician: Paul McCartney
Linda was more than just Paul’s wife. She also became a pianist for his band Wings, which he formed after the Beatles broke up. Not only did she help him weather the tumultuous period in his life, but she helped redeem his career as they became one of the most successful bands of the 1970s, even garnering an Oscar nomination for a song they co-wrote, “Live and Let Die.”

Designer: Riccardo Tisci
The Italian model famous for her extraterrestrial appeal is currently the muse for fashion house Givenchy by Riccardo Tisci. Over the years, she has appeared in several of his campaigns and has renewed her contract with the brand three times since 1997, after Tisci asked her to model for his line at a party where they first met.

Filmmaker: Woody Allen
Though Woody Allen’s earlier years in Hollywood with films such as Play it Again and Sam were nothing short of amazing, things got better when he teamed up with the beautiful Diane Keaton. She worked with Allen on three movies in the 1970s, including Sleeper and Love and Death. Oh, and there was also that little movie called Annie Hall that spawned the creation of one of the most iconic characters in cinematic history.

Designer: Henry Holland
The fashion designer and Vogue.com blogger says the model has always been his muse. Holland, known for his bold T-shirt designs, explained that his reason for drawing inspiration from Deyn wasn’t her looks, but that he’s always been influenced by her since they grew up together.

Designer: Karl Lagerfeld
A woman as smart, beautiful and industrious as Alexa can inspire anyone. Lagerfeld was sure moved by her as she was one of his inspirations behind his designs featured in Chanel’s Collection show. It’s like when you look at Alexa Chung, the world’s suddenly a colorful place.

Filmmaker: Woody Allen
Before they began working together professionally in the '80s and '90s, Farrow and Allen carried on a romantic relationship. Obviously, he was stricken with so much admiration for the woman that he became obsessed with capturing that beauty on camera. She starred in his films Broadway Danny Rose, The Purple Rose of Cairo, Hannah and Her Sisters, Radio Days, Alice, and three more after.

Musician: Bob Dylan
As the girl in his arms on the cover of The Freewheelin’ Bob Dylan, Suze Rotolo is part of one of the most recognizable images in music history. She began dating Dylan when she was 17, and inspired songs like "Don't Think Twice, It's All Right," "Boots of Spanish Leather" and "Tomorrow Is a Long Time."

Filmmaker: Woody Allen
At 16, Mariel was cast as Woody Allen’s love interest in the classic 1979 film Manhattan. Although she was among a cast of some of the most talented adult actors ever, Allen’s camera displayed her in a way that made audiences realize why his character fell in love with her in the first place. She made such an impression that she was nominated for the “Best Supporting Actress” Oscar.

Designer: Tom Ford
Moore’s inspiration extends beyond Ford's designer collection. While the redhead actress is known to don a number of his pieces at various red carpet events, her influence came to life on the big screen as she was cast as the female lead in his Oscar-winning film A Single Man.

Musician: Kanye West
You want to know who woke up Mr. West in class? This woman. Though she’s now dating rapper Wiz Khalifa, the beautiful American model first came to the limelight when she was with Kanye West. With a voluptuous figure and a luscious pair of kissers, it’s hard not to be inspired.

Photographer: Tyler Shields
After several memorable erotic photo shoots together, it’s easy to say Lohan has become of one Shields’ favorite subjects. It seems as though the photographer can get her to pose in ways that exist only in our most screwed up dreams. Through Shields’ lens, we’ve seen Lindsay as a bloody, knife-wielding vixen, a gun-totting goddess, a blood-thirsty vampire, Linda Lovelace and an oversexed socialite. Thanks, dude.

Designer: Karl Lagerfeld
Blake Lively has become the real life embodiment of her Gossip Girl counterpart, Serena Van der Woodsen, the socialite/muse of New York. Not only has she gotten many celebrity men to fall for her, but she caught the eye of one of fashion’s most beloved designers, Karl Lagerfeld, who admitted she was the inspiration for his Chanel Spring/Summer 2011 collection.

Musicians: George Harrison, Eric Clapton
Forget Yoko Ono, there was another woman in another Beatles’ life that significantly the rock stars of past. Formerly George Harrison’s and Eric Clapton’s wife, Boyd was also said to have attracted John Lennon and Mick Jagger. Her relationship with Harrison and Clapton led to the production of well-known songs such as Harrison's "Something," "I Need You," "For You Blue" and "Isn't It a Pity," and Clapton's "Layla," "Wonderful Tonight" and "Bell Bottom Blues.”

Designer: Karl Lagerfeld
For years, Lagerfeld couldn’t take his lens off the supermodel. The two have been working together for almost two decades, most recently for his new Chanel sunglasses campaign. Their relationship has become so famous that an “anniversary book” entitled Claudia & Karl, i.e. Lagerfeld’s portfolio of Schiffer photos, has been published to celebrate their 20 years of work together.

Filmmaker: Woody Allen
It wasn’t until Vicky Cristina Barcelona that Allen took notice of a woman outside of his white city girl scope. Clearly, he was inspired by the Spanish beauty, and gave her the direction that led to her Oscar win for “Best Supporting Actress.”

Designer: Alexander Wang
As the designer's stylist, Wang not only trusted Wasson as his main model but also as the trained eyes to critique his designs while he was still an up-and-coming designer. The two carried on a famous professional relationship for two years before parting ways in 2008. Yet, she still remains a part of his shows by providing him with jewelry from her line, Low Luv.

Artist: Banksy
Banksy recognized Kate Moss in the same way Warhol recognized Monroe: as one of the most iconic women of their generation. Emulating Warhol’s style, Banksy created a classic pop art piece with Moss’ likeness. Many other artists, designers, and musicians might lay claim to her as their inspiration, but Banksy’s efforts are arguably the greatest and most recognizable.

Filmmaker: Robert Rodriguez
Thanks to Rodriguez, Salma got her breakthrough roles in Desperado and From Dusk ‘til Dawn, among other films he's behind like Spy Kids and The Faculty. Thanks to him, we'll forever have an image of Salma in a corset, cowboy boots and gun in hand plastered in our minds.

Filmmaker: Woody Allen
Scarlett has starred in three of Allen's films: Match Point, Scoop and Vicky Cristina Barcelona. The filmmaker has never been coy about his love for ScarJo either, often gushing about her in interview. Okay, okay, we confess. We love Scarlett Johansson, too.

Designer: Karl Lagerfeld
You might struggle to pronounce her name properly, but it's hard to talk when your jaws on the floor, anyway. Erichssen rocked Karl Lagerfeld’s brand like she owned the damn thing, with her piercingly sexy looks and fierce demeanor. As one of the most popular and beloved models in the industry today, it makes sense why the sexually ambiguous beauty charmed Lagerfeld as well.

Filmmaker: Roger Vadim
You can thank Bardot’s former husband Roger Vadim for introducing the world to the French model and actress, Brigitte Bardot. The director, who had been infatuated with Bardot since seeing a modeling photo of her in Elle taken when she was a teenager, is credited with launching her career in his 1956 film And God Created Woman.

Artist: Andy Warhol
Edie Sedgwick became the most influential and notable inspiration for the famous pop artist. 1965's "Girl of the Year” was the focus of Warhol’s several short films shot at The Factory, including the Poor Little Rich Girl saga. She was also involved with Bob Dylan and other artists of the time, but she'll always be remembered for her proximity to Warhol. Their relationship was eventually reborn for the screen in her 2006 biopic, Factory Girl.