Date: January 2009
Target: Lil' Wayne
Best Line(s): "Don't end up on the fucking list, nigga. Be a missing person, like Cam'ron, like Ja, like Joe."

Who says 50's not generous? After Lil' Wayne threw a shot 50's way—"I'm all about a dollar, fuck two quarters / Bitch I'll pour syrup in that Vitamin Water"—50 gave out some free advice: fuck with 50, and he'll personally end your career (see Ja Rule, Fat Joe, and Cam'Ron). Spoiler alert: 50 and Wayne ended up posing for pictures together, after Floyd Mayweather's triumph in Las Vegas, May 5, 2012. So, all's well that end's well?