Included in the original formula for Gatorade was cyclamate, a sweetener that was banned by the FDA in 1969. As it turns out, cyclamate has some very problematic side effects; the most important is that it was discovered to be a carcinogen that caused bladder cancer. Obviously, Gatorade immediately pulled the chemical out of the drink and added more of the standard fructose. Thanks to the switch, now the most serious side effect of excessive Gatorade is merely obsesity and Type II diabetes!