Now that the question of Disney keeping the R-rating for the Deadpool sequel is out of the way, it's time to dive into what the film will actually contain. And with that, we present the below image, which Deadpool star Ryan Reynolds posted a few days ago. Sure, it's Michelangelo’s Sistine Chapel fresco The Creation of Adam starring Deadpool 2 characters Cable and Deadpool, but for fans of Cable's comic books and his adventures with Deadpool, there's so much more going on here.
As Uproxx put it, it would appear that this art has not only further confirmed what this sequel's plot will be based on, but they even speculate on what the official title of this sequel will be called. Here's a brief look at why they (and now, I) believe that this Deadpool sequel will officially be called Deadpool: The Second Coming. And no, this has nothing to do with ejaculate (although it is Deadpool, so expect a joke about that to hit at some point).
As you can see in the above image, the main words in there are "The Second Coming." That shouldn't be a coincidence, as one of the most massive Marvel X-Men comic book events was X-Men: Second Coming. What did that story deal with? Cable and the first child born with the mutant X-gene (Hope) since the Decimation of the mutant population in the Marvel universe (depleting the number of mutants to roughly 198). Second Coming was the third installment of Cable and Hope's story, following "Messiah Complex" and "Messiah War," featuring Cable, who'd brought Hope to the future to avoid being harmed by the many entities looking to control her, and returning to the present.
Keep in mind, Deadpool wasn't featured in this event, although there was a comic (Cable #25, which was renamed Deadpool and Cable #25) that was a retelling of Hope's birth, and how Deadpool played a part in helping Cable save her. That's not to say that this film (if it even is called Deadpool: The Second Coming), will be based on that comic, or stick to the X-Men: Second Coming event; it could very well tie key points of the entire arc of the Messiah Complex/Messiah War/Second Coming arc into one film.
Aside from the title, Cable's not only seen emerging through a time-travel portal, but he has a teddy bear strapped to his belt. We saw this image back in August via Josh Brolin's Instagram. It'd make sense that this bear would be Hope's, and at some point, Cable is going to need Deadpool's help in protecting Hope, as she is the future of the X-Men.
We still have some time before Deadpool 2 hits theaters on June 1, 2018; without an official trailer showing plot points, we're all just fantasy booking the X-Men Cinematic Universe. These teasers (which should fall in line with Reynolds' comment about there being Easter Eggs embedded all over the film) definitely feel like we're on the right track, though.