Drew Barrymore achieved success early on in life with a role in 1982’s E.T.: The Extra-Terrestrial, and by the time she turned 13, it seemed like she’d end up losing said success early on as well. Barrymore, like many who are exposed to Hollywood too young and too quickly, was dealing with numerous substance abuse issues, and she had been in rehab twice—once for drugs and alcohol, once for a suicide attempt—before she turned 15.

After a period cultivating the image of a Hollywood bad girl (going nude as a seductress in Poison Ivy, posing nude for Playboy, and flashing her breasts to David Letterman on the air for his birthday), she found legitimacy alongside Whoopi Goldberg and Mary-Louise Parker in 1995's Boys on the Side. Her cameo in the horror mega-hit Scream a year later became one of the most iconic scenes in cinema, and she followed that up with the Adam Sandler comedy The Wedding Singer in 1998, which started her on a roll of successful rom-coms (Never Been Kissed, 50 First Dates, Fever Pitch). Now, at 37, Barrymore is undeniably A-List, and she co-runs her own production company, Flower Films.