Stars: Kelsey Grammar, David Hyde Pierce, John Mahoney

The aforementioned Cheers spinoff, Frasier took its titular character played by Kelsey Grammar away from Boston and the beloved Cheers to a swanky (and way too big) Seattle apartment. Frasier united the titular psychologist and popular radio show host with his retired father (the late, great John Mahoney) and his neurotic brother Niles Crane (David Hyde Pierce). All together, these high class characters regularly got into faux pas and various farces, thanks to their collective fastidiousness, making audiences laugh for a decade and earning 37 Emmys (more than Cheers!), which was the record for a scripted series at the time.