Game: Resident Evil (1996)

Tyrant is huge, fast and no genitals. No wonder why this beast has anger management issues. When you first meet the mutated super soldier, he's asleep in a tube. Just the traitorous Wesker wraps up his speech, the goliath breaks free and runs his talons through the STARS Judas. Tyrant is hard to stop; even shooting his exposed heart weak spot doesn't mean a quick kill. With his bursts of unmatched speed, this boss gave Resident Evil fans the best reason to hold their breath.