The Height of Mayan Civilization
Until the Spaniards rolled in and crapped all over everything the Mayans had every created, the South America natives were an incredibly advanced people. Their advanced art and culture were second in popularity only to their super-fun human sacrifice, they had a written language way before it was cool on that continent, and they even predicted the end of the world.
There's plenty of room for intriguing stories to take place during the height of this incredible civilization, right up to its conquest by the Spanish during the 16th century. Although you could also argue that Zuma encompasses everything you need to know about this culture.