7. KATE GOSSELIN

When: April 1, 2010
Comment: "I don't like people that are famous because [she had a lot of children]. I don't know what kind of mother has that many children. I don't know how many children she's up to right now. From what I hear, the [Dancing with the Stars] rehearsals are pretty laborious. It's like four to six hours a day. You have eight children - that's pretty important."

Chelsea Handler's expertise is arguably ethering reality TV superstars. On an episode of Larry King Live, Handler insulted her easiest target, the mom stretching out her 16th minute of fame, Kate Gosselin.