Score: #12 Missouri 93, #5 Miami 80

There's nothing particularly shocking about the #12 seed knocking off the #5 seed in the NCAA Tournament (in fact, you'll only see two of them, including this one, mentioned on this list) but thanks to the hot hand future NBA baller Kareem Rush had in this game—and in every game that Mizzou played in this tourney—the Tigers managed to advance all the way to the Elite Eight before taking an L to #2 Oklahoma.

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