In Hitman: Absolution, it's Agent 47's job to keep somebody alive, for once.
It seems he's been asked to protect a seemingly random girl living in a Chicago orphanage. Whatever the reason, she clearly needs his help: A group of thugs has been hired to abduct her in the middle of the night.
Just because protecting a life is the ultimate goal, doesn't mean the hitman's not going to kill a lot people to get the job done.
Hitman: Absolution will sneak up on you later this year.