Alien 5 is going to straight pretend that Alien 3 and 4 (aka Alien Resurrection) didn’t happen, and just be a sequel to Aliens. Because that won’t be confusing.
District 9 director Neil Blomkamp was recently announced as helming the next Alien sequel, and he told Sky Movies that he was going to ignore the often-hated third and fourth Alien films, and just follow on from part two. "I want this film to feel like it is literally the genetic sibling of Aliens. So it's Alien, Aliens, this movie"
Alien Resurrection is generally hated by everyone, but Alien 3 has gained somewhat of a cult following since initially opening to bad reviews. Sigourney Weaver’s Ripley was blown up in part three, and then came back as a clone in four, so maybe this will make things simpler. No word on how Prometheus or those awful Alien Vs Predator films will fit into this, but as long as it’s a good film filled with scary AF space monsters, we’ll be happy.
And anyway, the last time anyone this happened was with the Superman movies, and look how well Superman Returns turned out…