Episode: "Go God Go” (s10e12)
Original Air Date: November 1, 2006

One of the more cult and obscure video game references in South Park, Okami boxes frequently dot the store shelves of EV Games throughout multiple seasons. It's not hard to imagine that Parker, Stone, and their writing team absorbed most of their game references by indirect osmosis of the biggest name games. But a direct reference to a game as niche (relatively speaking) and critically acclaimed as Okami seems to suggest that the writers had some personal, positive experience with it. The next step is a correctly spelled allusion to Amaterasu - and not the Marvel vs. Capcom 3 version.