City: Las Vegas
Also Destroyed In: Resident Evil: Extinction; Category 6: Day of Destruction; 10.5 Apocalypse; and 2012

While lives were nearly destroyed here in The Hangover, and careers had to be destroyed in the making of this t-shirt, Vegas has not been destroyed on film too many times. But when filmmakers do destroy the Strip, they go in. The explosion of Sin City in Mars Attacks! used the footage from the actual demolition of the Landmark Hotel. No special effects here.