2. Poison

Game Appearances: Final Fight, Street Fighter X Tekken

Original Gender: Male

Probably the most famous transgendered character on the list, Poison's confusing sexual status has puzzled gamers for years. Though the original character started as a female in the Japanese version of Final Fight, she was changed to a transexual man for the American release to accomodate cultural sensitivities about beating up women. The ensuing confusion was eventually rolled into the character's canonical story and we're left with one of the most unique fighters in Capcom's roster.

To make things a little more confusing, Yoshinori Ono stated that in North America Poison is a full-blown post-op transsexual, but in the Japanese versions she still has a little something extra tucked away.