You Have Died of Dysentery
Origin: The Oregon Trail
Pioneer life was no picnic, but that doesn't mean we can't laugh at their misfortunes! There's nothing more horrific than losing a loved one to a debilitating disease like dysentery, but as one of the few programmed ailments in The Oregon Trail it became a sticking point for gamers stuck playing the title during computer class in the 3rd grade.
If there's one thing that damned game taught us it's that a grueling pace will often lead to sudden and irreversable death.