Despite the list of mental ailments that’ve surfaced throughout the show’s six seasons, Aspberger’s Syndrome, which typically involves the socially awkward inability to recognize emotion in other people, noticeably has yet to make a cameo. It's become more of a hot topic in the health world over the past five years or so, making it seem like a prime target for the show's producers. But how to bring it up? In terms of its potential plotline, we don't have any doubt that it would make its big appearance with one of Charlie or Dennis’ future love interests. No question.