'Friends' Actor Matthew Perry Died of 'Acute Effects of Ketamine'

The toxicology report also stated the contributing factors to Perry’s death were drowning, coronary artery disease, and the effects of buprenorphine.

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Matthew Perry’s cause of death has been revealed as “acute effects of ketamine,” according to the Los Angeles County Medical Examiner’s Office.

The toxicology report also stated that the contributing factors to the Friends actor’s death included drowning, coronary artery disease, and the effects of buprenorphine (used to treat opioid use disorder).

Authorities found Matthew Perry dead in his Los Angeles home in a hot tub around 4 p.m. on Oct. 28. There were no immediate signs of foul play or drug use on the scene. The manner of his death was ruled an accident.

“We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family. There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss,” Perry’s Friends cast members Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer wrote in a statement. “In time we will say more, as and when we are able. For now, our thoughts and our love are with Matty’s family, his friends, and everyone who loved him around the world.”

Aniston added, “He was happy. He was healthy. He had quit smoking. He was getting in shape. He was happy—that’s all I know. I was literally texting with him that morning, funny Matty. He was not in pain. He wasn’t struggling. He was happy.”

Cox said, “I am so grateful for every moment I had with you Matty and I miss you every day. When you work with someone as closely as I did with Matthew, there are thousands of moments I wish I could share. For now here’s one of my favorites.”

Friends aired on NBC from 1994 to 2004, with the cast reuniting in 2021 for HBO special Friends: The Reunion. The following year, Perry released his memoir, Friends, Lovers, and the Big Terrible Thing: A Memoir, which followed the actor's journey through his career, alcoholism, drug addiction, and recovery.

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