Most Memorable Roles: Neytiri in Avatar (2009)

Zoe Saldana has made a name for herself playing otherworldly females. First, the half-Dominican actress became the first lady of the USS Enterprise as Lieutenant Uhura in Star Trek. And while we didn't actually see her in the flesh in Avatar, she nonetheless earned her place in Hollywood's A-list with the fiery charisma in her motion-capture acting.