Most Memorable Role: Brenda Meeks in Scary Movie 1-4 (2000-2006)
Regina's most known role, Brenda in the Scary Movie franchise, somehow survived stabbings and fatal curses from creepy girls crawling out of TVs. She won't be in the upcoming Scary Movie 5, and yet for her one-liners, Brenda will live on as our favorite scream queen.