Do A Barrel Roll
A simple command made funny thanks to one intrepid hare's repetition was made even funnier by the constant repetition from the Internet en masse.
What started as a simple measure to dodge incoming enemy fire turned into a way to deflect any conversation into outright hysterics.
Though it took almost a decade between the game's release and the meme's creation, it has become one of the most ubiquitously recognized memes in video game history. For a little extra fun, try typing the phrase into Google; you won't be disappointed.