4. MARIAH CAREY

When: January 2012
Comment: "She's worse than Elizabeth Taylor. She's just so ridiculous with her body. You see her one day and she's like 50 pounds heavier or lighter, I mean what is she doing? I don't even understand what hemisphere people like that operate in. There's nothing real about her and her Hello Kitty whatever."

It's no secret that Handler isn't Carey's biggest fan. On Howard Stern's radio show, Handler took out her aggression one of her most targeted couples, Nick Cannon and Mariah Carey.