Network: NBC

The show that made Gary Coleman a household name, Diff'rent Strokes told the story of two brothers from Harlem who were adopted by the wealthy businessman that their mother worked for after she passed away. Thank the show for any popular culture and hip-hop references to "Phil Drummond" as a symbol of wealth.

Still, the show's most well-known characters were Coleman's Arnold and his older brother Willis, played by Todd Bridges. In fact, Willis might be the show's most recognized character, thanks to Arnold's catch-phrase "Whatchu talin' bout, Willis?" Biggie might've called it "played out" on "The What," but it was the show's trademark.

Aside from Arnold's famous question, Diff'rent Strokes was recognized for episodes that focused on serious issues like drugs, molestation, race, violence, and eating disorders. Unfortunately, each of the show's three child stars (Coleman, Bridges, and Dana Plato) struggled with drug addiction and legal troubles after the show ended. Plato died of a drug overdose in 1999, and Coleman died at 42 after falling and hitting his head in 2010. Only Bridges survived his struggles. Despite the sad ending for the show's young stars, Diff'rent Strokes will live on as one of the 20th century's most important programs.