Location: Louisville, Ky., Cincinnati, and Bentonville, Ark. 
Year: 2006

21c Museum Hotel aims to integrate contemporary art into the everyday lives of their guests. The first 21c Museum Hotel started out as an initiative by art collectors Laura Lee Brown and Steve Wilson to revitalize Louisville. They boldly converted five abandoned warehouses into this charming boutique hotel, which houses impressive art installations. Since then, the art hotel chain has expanded to other cities.