1. Natascha McElhone as Karen
In a perfect world, Hank would find a way to curb his self destructive man-whoring ways and wind up with Karen, played by the flawless Natascha McElhone. She's not only Hank's baby mama and muse, but also the love of his life. No matter which new women enters Hank's life, or bed rather, he always winds up trying to make things work with Karen.