Producer: Hit-Boy
Album: Cruel Summer
Label: G.O.O.D. Music, Def Jam

Originally titled "Theraflu," this Kanye West single came out of nowhere to set the Internets on fire. Dropping Anna Wintour's name and taunting PETA in the same breath, acknowledging his relationship with Kim Kardashian and needling her ex Kris Humphries, this song was packed with quotables for every occasion. ("Don't talk about style cause I'll embarrass you," anyone?) But what makes it a Chi-town anthem is Power 92 radio fixture DJ Pharris shouting out all those Windy City neighborhoods on the outro. Chicago stand up. —Rob Kenner