53. 2Pac "Ambitionz Az A Ridah" (1996)
Producer: Daz Dillinger
Album: All Eyez On Me
Label: Death Row, Interscope
Who would have thought that Joeski Love's 1986 novelty hit, "Pee Wee's Dance" could sound so menacing? The addition of urgent strings, a tense piano riff, and high-end synth line gives the instrumental a "Butch Cassidy and The Sundance Kid" feel to it, which serves as a fitting backdrop to 2Pac's verbal assault as he blacks-out on his enemies. Everyone from G-Unit to Lil Wayne to Cam'ron (who flipped it into the memorable "Live My Life") has rapped over this beat, which became a freestyle staple.
Related: The 100 Best 2Pac Songs