Mangle your hand in a feed chopper and lose most of your index finger? Rub some dirt on that nub and get back in the game! Mordecai Brown lopped off his pointer finger in a farm accident as a kid (and then broke his middle finger and didn't have it set properly) but went on to have a Hall of Fame career, including a year in which he went 27-9 with 32 complete games in 342 innings—and also led the league in saves. And today pitchers go on the DL with blisters!
22. Mordecai "Three-Finger" Brown