3. Gene Tierney
Most Infamous Moment: Tierney had a fling with a young John F. Kennedy, who couldn't pursue their relationship further because of his political ambitions. She voted for Nixon.
After contracting rubella from a fan who snuck out of quarantine to see her, Tierney had a premature birth to her daughter, who was born deaf, partially blind, and mentally challenged. It is possible that the knowledge of her contracting the disease from a fan caused her bipolar issues.
After filming The Left Hand of God, Humphrey Bogart encouraged her to seek help. Tierney went to an asylum, where she received 27 shock treatments, tried to escape, and was re-institutionalized.