We'd be lying if we claimed that this hasn't crossed our mind before, though Uncharted isn't the example we'd use.
What about in Bioshock, where enemies don't reset when you die—you don't return to a previous checkpoint, you simply respawn and take the fight directly back to them. Plus those splicers are tweaked out as fuck to begin with. That must be the scariest experience of their soon-to-end lives.
Have you ever thought about how scary life is for video game bad guys? Tell us what you want in the comments or on Twitter.