Probably. X17 reports that Aniston, who's doing press for the Adam Sandler film Just Go With It, revealed to Oprah Winfrey that she was actually asked to be a cast memeber on Saturday Night Live. "They were like, 'You're so stupid,'" she said about the fact that she turned them down. "They thought I was making a huge mistake."
For the record, if anyone was going to make a mistake in that scenario it was SNL and Lorne Michaels. Aniston is many things, but it's hard to imagine her being consistently funny in live comedy sketches. Of course, that might not be what Michaels was looking at when he auditioned her. Witness this GIF of Aniston's only hosting appearance of SNL. You're welcome.