1. The Boss, Metal Gear Solid 3: Snake Eater (PS2, 2004)
We’ll try not to spoil too much on this one, because her story deserves to be experienced first hand. The final curtain for The Boss’ arc is heart-crushing, and no other villainess in gaming history has been given such full-blooded treatment by either protagonist (Snake) or creator (Hideo Kojima).
If you haven’t already played MGS3, do it now. You’ll see why #1 was a no-brainer for us. And you’ll see why she was truly the origin of Metal Gear lore.