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21. Epidemic.com

Year: 2000

The viral marketer spent 1.6 million to promote its online referral compensation site. If you couldn't tell, the ad does a horrendous job of selling you on the service, and after burning through its first round of funding (est. $7.6 million), Epidemic.com became just another victim of the dot-com crash.

Tags: super-bowl, commercials, go-daddy
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