2. Mike Tyson bites off Evander Holyfield's ear.
Punishment: Stripped of boxing license in Nevada, fined $3 million
Perhaps the most infamous of all in-game infractions, Mike Tyson had reached the end of the line of his once-promising career heading into this rematch with Evander Holyfield. After deciding that he didn't like the way Holyfield was headbutting him during the fight (and the way it was going unpunished by referee Mills Lane), Tyson decided the only way to get Holyfield's attention was to bite him. After being cautioned and losing two points after his first nibble, Iron Mike went big and fully ripped off a piece of Holyfield's right ear. Understandably, the match was stopped and Tyson was disqualified.