Year: 2006
Game: Heat vs. Lakers

With Shaq out due to injury, Wade was put on the big stage against Kobe. Flash dominated throughout and held Kobe to 16 points on 4-17 shooting. Dwyane scored 40 points on 12-20 shooting, grabbed 4 boards, had 11 assists, 4 steals and 4 blocks for the hell of it. That's a line you can only get in a game of 2K. Wade's performance led he Heat to a 101-85 victory.