Annual earnings: $55 million
Biggest flop: The Fountain (2006)

Had Darren Aronofsky chosen to add a few song-and-dance numbers to his indie sci-fi film, which traces an epic love story over a thousand years, things might have been different. And while The Fountain has its fair share of rabid fans, its detractors—including several critics who booed the film when it premiered at the Venice Film Festival—have won the numbers game. Shot on a budget of $35 million, the film racked up just $15,461,638 in box office receipts.