Funniest Role: Grace Adler on Will & Grace
Memorable Quote: "I'm not going to be funny, I'm just going to be earnest."
Most actresses spend their entire career chasing the accolades Debra Messing has complied over the years. Her eight-season run as Grace Adler on Will & Grace was groundbreaking as it was the first TV series to star openly-homosexual lead characters. Six Emmys and eight Golden Globes later, Messing had cemented her legacy as one of the most decorated sitcom actresses of all time. Oh, and lest we forget, during that time she even earned a a well-deserved nod for People's "50 Most Beautiful People in the World" in 2002.