6. Lil Wayne f/ Juvenile & B.G. "Tha Block Is Hot" (1999)
Producer: Mannie Fresh
Album: Tha Block Is Hot
Label: Cash Money, Universal
Riding Cash Money's hot streak, Wayne's debut solo single, "Tha Block Is Hot," was a giant step for the then-17-year-old. It introduced the world to Wayne as not just a tiny hypeman for Juvenile, but as a lively and entertaining standalone force. He splatters his still-tightening flow and cartoony vocal effects all over Mannie's impending track.