The Notorious B.I.G.
What Happened?: While recording for his second album, Christopher Wallace suffered serious injuries in a car accident when Lil Cease lost control of their rented vehicle on a rainy day. His left leg was shattered and he was confined to a wheelchair for weeks.
How He Responded: Biggie rhymed about the incident on "Lost Kiss Goodnight" when he said "I used to be as strong as Ripple be / Till Lil Cease crippled me." Due to his injuries, Biggie was forced to walk with a cane for the rest of his life. That certainly led to some lifestyle changes, but it also went well with his playboy persona when he started donning Versace suits and gator shoes.