The movie: The Hangover (2009)
The player(s): Bradley Cooper, Ed Helms, Zach Galifianakis and Justin Bartha

Put Zach Galifianakis in any situation and there's bound to be big laughs. But surround him with a posse—including the smooth-talking Phil (Cooper), a strait-laced dentist (Helms) and that other guy (Bartha)—and you've got a full-on wolf pack... one worthy of two sequels and more than $600 million in box office receipts.