The movie: Mallrats (1995)
The player(s): Jason Lee

Really, any sort of collectible could replace "comic books" in this scenario. But when Kevin Smith is at the helm, there's bound to be one obsessive comic collector in the mix. In the case of Mallrats, Smith's follow-up to the wildly popular Clerks, it's Brodie (Lee) who plays the part (and, yes, he lives in his parents' basement). And even gets some advice on life and relationships from Stan Lee. It's worth noting that Smith himself is a comic book writer and owns Jay and Bob's Secret Stash, a comic store in Red Bank, New Jersey.