After Harry (Billy Crystal) met Sally (Meg Ryan), but before they'd got serious and married, the titular couple tried setting each other up on a blind, double-date: Harry with Marie (Carrie Fisher) and Sally with Jess (Bruno Kirby). But Marie and Jess only have eyes for each other.

Minutes after separately promising their friends that they'd spare everyone's feelings and not act on their attraction that night, they find an excuse to share a cab home, leaving Harry and Sally in the dust.