The 15 Most Unexpected Celebrity Hook-Ups of 2012 Photo via Daily Mail

Seth MacFarlane and Emilia Clarke

When: September-November

Though he recently tweeted that he's a single man, this fall, 38-year-old Seth MacFarlane, the brains behind Family Guy, American Dad and Ted, dated Emilia Clarke, the 24-year-old beauty who plays Daenerys Targaryen on HBO's Game of Thrones. Yes, the voice of Stewie Griffin got it on with one of the sexiest British starlets in the world.

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