Played by: Naya Rivera
TV ShowGlee

On Glee, Naya Rivera plays Santana Lopez, a tough-as-nails alumna of William McKinley High who comes from Lima Heights, which, as any Gleek knows, is the wrong side of the tracks. Santana, who was recently revealed as a lesbian despite having previous relationships with male cast members, is always quick with an insult or a plan to take someone down.