Funniest Role: Annie Walker in Bridesmaids (2011)
Memorable Quote: "If I were 21 and doing this commercial, I'd be all about what I look like. Now I'm like, 'Hell yeah! I'll sit on this couch and eat this yogurt that makes you crap!'"

What makes Wiig so hilarious is her dedication to her characters. In The Joe Schmo Show, the reality show where everyone was an actor except one man, Wiig stayed in character while being injured and sent off to the hospital. Wiig is so dedicated that she has no qualms about carrying baby hands and discussing eating squirrels to Hollywood hunks on SNL or dramatically watching her friend poop in the street in her film Bridesmaids. And it takes a really hot lady to still be attractive after all of that.