Funniest Role: Penny on The Big Bang Theory
Memorable Quote: "You do a job; your show gets canceled. You get used to it."

If landing roles in critically acclaimed TV shows is your baseline for measuring an actress' hotness, then Kaley Cuoco should rank pretty high in your system. Since bursting on the scene as in 2002 as Bridget Hennessy on the Emmy Award-winning TV show 8 Simple Rules, she has gone on put together an impressive run of gigs, including her current tenure as the hot girl-next-door (with a heart for geeks) in the Golden Globe-winning comedy series The Big Bang Theory.