Funniest Role: Rachel Green on Friends
Memorable Quote: "When someone follows you all the way to the shop and watches you buy a toilet roll, you know your life has changed."
Aniston played Rachel, the post-nose-job spoiled hotty from one of the greatest sitcoms to ever grace the world, Friends. Not only did her role inspire one of the largest haircut crazes to sweep the nation, but she also became a staple in the rom-com genre. She played the gorgeous love interest in Bruce Almighty, Just Go with It, and—we're still crying over it—Marley and Me.